Valporin CR 300 Tabletis a controlled-release formulation containing Sodium Valproateequivalent to 300 mg. 
It is manufactured by Renata PLC in Bangladesh.  

Each enteric-coated controlled-release tablet contains:

• Sodium Valproate BP 199.8 mg
• Valproic Acid BP 87 mg(Total equivalent to Sodium Valproate 300 mg)

Indications:

Valporin CR is indicated for the treatment of:

• Partial seizures.  
• Absence seizures (petit mal).  
• Generalized tonic-clonic seizures (grand mal).  
• Myoclonic seizures.  
• Atonic seizures.  
• Mixed seizures that include absence attack.  
• Prophylaxis of febrile convulsion.Prophylaxis of post-traumatic epilepsy.  
• Bipolar disorder.  
• Prophylaxis of migraine.  

Pharmacology:

Sodium Valproate, the active ingredient of this preparation, possesses anti-epileptic activity against a variety of seizures.The mechanism by which Sodium Valproate exerts its anti-epileptic effects has not been established.  

Dosage and Administration:

The dosage is individualized and should be administered as advised by the physician. Some general guidelines:

• Adult Epilepsy: Usually started at 600 mg daily in 2 divided doses, increasing every 3 days by 200 mg until seizure control is achieved (usual range 1-2 g daily).
• Children (over 20 kg):Initial dose 400 mg daily in divided doses, increased until control (usual range 20-30 mg/kg daily, max 35 mg/kg daily).  
• Bipolar Disorder:Initially 600 mg daily (20-30 mg/kg/day) in 2-3 divided doses. The maintenance dosage is 1000-2000 mg daily. 

Prophylaxis of Migraine:400-600 mg daily, although some may require higher doses.  

Febrile Convulsion: 20-30 mg/kg/day in 3 divided doses.

Valporin CR tablets should be swallowed whole and not crushed or chewed.It is usually taken with or after food to minimize gastrointestinal upset.  

Contraindications:

Sodium Valproate is contraindicated in patients with:

• Known hypersensitivity to the drug.  
• Liver dysfunction.

Precautions:

• Liver functions should be monitored before therapy and during the first 6 months, especially in patients most at risk.
• Care should be taken in renal impairment, pregnancy, breastfeeding, and systemic lupus erythematosus.
• Sudden withdrawal of therapy should be avoided.

Side Effects: 

The most common side effects are anorexia, nausea, and vomiting. However, these side effects are minimized with the use of enteric-coated tablets. Effects on the CNS include sedation, ataxia, and tremor. Rash and alopecia have been observed occasionally. Valporin CR may cause elevation of liver enzymes in plasma.  

Drug Interactions:

Valporin CR appears to act as a non-specific inhibitor of drug metabolism. Drugs with which it interacts most significantly are Phenobarbital, Phenytoin, Warfarin, Aspirin, Carbamazepine, and Lamotrigine.

Storage:

Do not store above 30°C. Keep away from light and out of reach of children.

Important Note:

This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.