Vivori (Voriconazole): Advanced Azole Antifungal Treatment

Vivori is a high-potency triazole antifungal medication containing Voriconazole. It is an essential treatment for patients aged 12 and older suffering from severe, life-threatening fungal infections.

📋 Indications: What Does Vivori Treat?

As a broad-spectrum azole antifungal, Vivori is indicated for:

• Invasive Aspergillosis: A serious fungal infection affecting the lungs.

• Candidemia & Disseminated Candidiasis: Fungal infections in the blood, skin, abdomen, kidneys, bladder, and wounds.

• Esophageal Candidiasis: Yeast infections affecting the throat/esophagus.

• Scedosporium & Fusarium Species: Potentially fatal infections including Fusarium solani.

• Refractory Infections: Used when patients are intolerant of or do not respond to other antifungal therapies.

🥄 Dosage and Administration Guidelines

For maximum bioavailability, oral Vivori should be taken at least one hour before or after a meal.

Oral Dosage (Tablets/Suspension)

Reconstitution of Oral Suspension

1. Shake the bottle to loosen the powder.

2. Add 25 ml of boiled and cooled water.

3. Shake vigorously until fully mixed.

4. Discard any remaining suspension after 14 days.

⚠️ Drug Interactions & Contraindications

Vivori is a potent inhibitor of CYP450 enzymes (CYP3A4, CYP2C9, and CYP2C19).

• Contraindicated Medications: Do not use with Terfenadine, Sirolimus, Quinidine, Rifampin, or Carbamazepine due to risks of toxicity or loss of efficacy.

• Monitoring: Dosage adjustments are required when co-administered with Phenytoin or Efavirenz.

🔬 Pharmacology & Side Effects

Voriconazole works by inhibiting ergosterol synthesis, which depletes the fungal cell membrane.

• Common Side Effects: Blurred vision, abdominal pain, headache, nausea, and diarrhea.

• Long-term Warning: Treatments exceeding 180 days increase the risk of Squamous Cell Carcinoma (SCC) of the skin.

• Pregnancy: Use only if the benefit to the mother outweighs the risk to the fetus.

📦 Storage Conditions

• Powder: Store between 2°C to 8°C.

• Reconstituted Suspension: Store between 15°C to 30°C.

• General: Keep in a dry place below 25°C, protected from light and out of reach of children.