Xtrafen (Aceclofenac): A Non-Steroidal Anti-inflammatory Drug (NSAID)

Xtrafen contains Aceclofenac, a non-steroidal drug with anti-inflammatory and analgesic (pain-relieving) properties. It is indicated for the relief of pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, toothache, trauma, and lumbago. Xtrafen belongs to the therapeutic class of Non-steroidal Anti-inflammatory Drugs (NSAIDs). 

How Xtrafen Works (Pharmacology)

Aceclofenac's mechanism of action is to inhibit an enzyme involved in inflammation: 

• Inhibits Cyclooxygenase (COX): It is a potent inhibitor of the cyclooxygenase enzyme. 
• Reduces Prostaglandin Production: This enzyme is involved in the production of prostaglandins, which are compounds that play a key role in causing pain and inflammation. 
• Anti-inflammatory and Analgesic Effects: By inhibiting prostaglandin production, Aceclofenac reduces inflammation and relieves pain. 
• Rapid Absorption: After oral administration, it is rapidly and completely absorbed as an unchanged drug. 

Key Indications & Benefits

Xtrafen is indicated for the relief of pain and inflammation in: 

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Toothache
• Trauma
• Lumbago

Dosage & Administration

The dosage of Xtrafen varies depending on the formulation. It is for adult use. Always consult a registered physician for specific dosage instructions. 

• Extended-release tablet: One 200 mg tablet daily. 
• Film-coated tablet: 100 mg twice daily. 

Important Considerations & Warnings

It is crucial to discuss your full medical history with your doctor before taking Xtrafen. 

Contraindications:

• Known hypersensitivity to Aceclofenac. 
• Patients in whom aspirin or other NSAIDs have triggered asthma attacks.

Side Effects:

• The provided information re-states the pharmacology of the drug in the side effects section. Common side effects of NSAIDs generally include gastrointestinal issues, but no specific side effects are listed here other than a repetition of the pharmacology. 

Pregnancy & Lactation:

• The use of Aceclofenac should be avoided in pregnancy and lactation unless the potential benefits outweigh the possible risks to the fetus or infant. 

Precautions & Warnings:

• Gastrointestinal Issues: Use with caution in patients with active or suspected peptic ulcers or gastrointestinal bleeding. 
• Organ Impairment: Caution should be exercised in patients with moderate to severe hepatic impairment, cardiac impairment, or renal impairment. 
• Other Conditions: Caution is also advised for patients who suffer from dizziness or urticaria (hives). 

Drug Interactions:

• While no significant interactions have been observed, close monitoring is needed with: 
  • Lithium and Digoxin: May increase their plasma concentrations. 
  • Diuretics: May interact with the activity of diuretics. 
  • Anticoagulants: May enhance their activity. 
  • Methotrexate: May increase its plasma level. 

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.